Exasperation

Ex*as`per*a"tion (?), n. [L. exasperatio: cf. F. exaspération.] 1. The act of exasperating or the state of being exasperated; irritation; keen or bitter anger.

Extorted from him by the exasperation of his spirits.
South.

2. Increase of violence or malignity; aggravation; exacerbation. "Exasperation of the fits." Sir H. Wotton.